Review



murine glioma cell line c6  (ATCC)


Bioz Verified Symbol ATCC is a verified supplier
Bioz Manufacturer Symbol ATCC manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
  • 96

    Structured Review

    ATCC murine glioma cell line c6
    Murine Glioma Cell Line C6, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1958 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6/pm41439468-272-31-39
    Average 96 stars, based on 1958 article reviews
    murine glioma cell line c6 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    Related Articles

    In Vitro:

    Article Title: Lessons on brain edema in HE: from cellular to animal models and clinical studies
    Article Snippet: Mouse – hyperammonemia - NH 4 CH 3 CO 2 (1–10 mM) , In-vitro : post-natal organotypic slice cultures – forebrain , Optical coherence tomography (OCT) - of cultured slices Confocal microscopy Immunoblotting , - ammonia for 3 days → evidence of tissue edema that is linked with astrocytic swelling - no significant changes in slice area were detected over 3 days at ammonia concentrations up to 10 mM - NH 4 CH 3 CO 2 10 mM resulted in macroscopic tissue swelling, with slice thickness increasing ~ 30%, treated: 441 ± 40 μm vs. control: 345 ± 33 μm - volume of GFAP-immunoreactivity was used as a marker of astrocyte cytoplasmic volume - the fractional volume of cortex occupied by GFAP- immunoreactive voxels progressively and significantly increased at concentrations of 1–10 mM of NH 4 CH 3 CO 2 - NH 4 CH 3 CO 2 10 mM resulted in 8% increase in volume of GFAP-immunoreactivity - no change in astrocytes number - neurons somatic diameter of control ranged from 10–15 μm vs. 20 μm after treatment with NH 4 CH 3 CO 2 10 mM associated with large swollen nuclei , Back et al. ( ) . .. C6 Glioma Cell line (AmericanType Culture Collection (Rockville, MD)) -hyperammonemia - NH4Cl (5 mM) + resveratrol (100 μM) , In-vitro : astroglia cells , Optical microscopy , - ammonia induced astrocyte swelling / cell body retraction, and resveratrol prevented this effect - ammonia induced increased expression of cytokines, the TNF-α, IL-6 and IL-1β, which was partially reversed by resveratrol (TNF-a levels from 148 ± 13% to 109 ± 13%, IL-1β levels from 140 ± 9% to 110 ± 13%, and IL-6 from 135 ± 13% to 115 ± 16%, values expressed as percentage of control) , Bobermin et al. ( ) . .. Brain cell 3D culture hyperammonemia - NH4Cl (5 mM) + creatine (1 mM) , In-vitro : mixed-cell aggregates – from mechanically dissociated telencephalon of 16-day rat embryos , Optical microscopy , - ammonia induced astrocyte swelling, and creatine prevents this effect - NH 4 Cl alters AGAT, GAMT and SLC6A8 expression in glial cells but not in neurons - increased GAMT but repressed SLC6A8 mRNA expression in oligodendrocytes - creatine co-treatment under NH 4 Cl exposure represses AGAT and SLC6A8 in swollen astrocytes - decrease of endogenous synthesis of creatine under NH 4 Cl exposure - ammonia exposure impaired axonal growth in developing mixed cell aggregates - creatine prevented ammonia-induced axonal growth impairment in developing mixed cell aggregates - creatine did not prevent the ammonia-induced axonal growth impairment in developing neuron-enriched aggregates - neuronal fiber growth impairment under ammonium exposure, together with a decrease in medium size neurofilaments (NF-M) - in mature aggregates ammonia exposure does not alter axonal morphology → difference in vulnerability of the developing and adult brain - no significant effect was found for oligodendrocytes , Braissant et al. ( ) .

    Microscopy:

    Article Title: Lessons on brain edema in HE: from cellular to animal models and clinical studies
    Article Snippet: Mouse – hyperammonemia - NH 4 CH 3 CO 2 (1–10 mM) , In-vitro : post-natal organotypic slice cultures – forebrain , Optical coherence tomography (OCT) - of cultured slices Confocal microscopy Immunoblotting , - ammonia for 3 days → evidence of tissue edema that is linked with astrocytic swelling - no significant changes in slice area were detected over 3 days at ammonia concentrations up to 10 mM - NH 4 CH 3 CO 2 10 mM resulted in macroscopic tissue swelling, with slice thickness increasing ~ 30%, treated: 441 ± 40 μm vs. control: 345 ± 33 μm - volume of GFAP-immunoreactivity was used as a marker of astrocyte cytoplasmic volume - the fractional volume of cortex occupied by GFAP- immunoreactive voxels progressively and significantly increased at concentrations of 1–10 mM of NH 4 CH 3 CO 2 - NH 4 CH 3 CO 2 10 mM resulted in 8% increase in volume of GFAP-immunoreactivity - no change in astrocytes number - neurons somatic diameter of control ranged from 10–15 μm vs. 20 μm after treatment with NH 4 CH 3 CO 2 10 mM associated with large swollen nuclei , Back et al. ( ) . .. C6 Glioma Cell line (AmericanType Culture Collection (Rockville, MD)) -hyperammonemia - NH4Cl (5 mM) + resveratrol (100 μM) , In-vitro : astroglia cells , Optical microscopy , - ammonia induced astrocyte swelling / cell body retraction, and resveratrol prevented this effect - ammonia induced increased expression of cytokines, the TNF-α, IL-6 and IL-1β, which was partially reversed by resveratrol (TNF-a levels from 148 ± 13% to 109 ± 13%, IL-1β levels from 140 ± 9% to 110 ± 13%, and IL-6 from 135 ± 13% to 115 ± 16%, values expressed as percentage of control) , Bobermin et al. ( ) . .. Brain cell 3D culture hyperammonemia - NH4Cl (5 mM) + creatine (1 mM) , In-vitro : mixed-cell aggregates – from mechanically dissociated telencephalon of 16-day rat embryos , Optical microscopy , - ammonia induced astrocyte swelling, and creatine prevents this effect - NH 4 Cl alters AGAT, GAMT and SLC6A8 expression in glial cells but not in neurons - increased GAMT but repressed SLC6A8 mRNA expression in oligodendrocytes - creatine co-treatment under NH 4 Cl exposure represses AGAT and SLC6A8 in swollen astrocytes - decrease of endogenous synthesis of creatine under NH 4 Cl exposure - ammonia exposure impaired axonal growth in developing mixed cell aggregates - creatine prevented ammonia-induced axonal growth impairment in developing mixed cell aggregates - creatine did not prevent the ammonia-induced axonal growth impairment in developing neuron-enriched aggregates - neuronal fiber growth impairment under ammonium exposure, together with a decrease in medium size neurofilaments (NF-M) - in mature aggregates ammonia exposure does not alter axonal morphology → difference in vulnerability of the developing and adult brain - no significant effect was found for oligodendrocytes , Braissant et al. ( ) .

    Expressing:

    Article Title: Lessons on brain edema in HE: from cellular to animal models and clinical studies
    Article Snippet: Mouse – hyperammonemia - NH 4 CH 3 CO 2 (1–10 mM) , In-vitro : post-natal organotypic slice cultures – forebrain , Optical coherence tomography (OCT) - of cultured slices Confocal microscopy Immunoblotting , - ammonia for 3 days → evidence of tissue edema that is linked with astrocytic swelling - no significant changes in slice area were detected over 3 days at ammonia concentrations up to 10 mM - NH 4 CH 3 CO 2 10 mM resulted in macroscopic tissue swelling, with slice thickness increasing ~ 30%, treated: 441 ± 40 μm vs. control: 345 ± 33 μm - volume of GFAP-immunoreactivity was used as a marker of astrocyte cytoplasmic volume - the fractional volume of cortex occupied by GFAP- immunoreactive voxels progressively and significantly increased at concentrations of 1–10 mM of NH 4 CH 3 CO 2 - NH 4 CH 3 CO 2 10 mM resulted in 8% increase in volume of GFAP-immunoreactivity - no change in astrocytes number - neurons somatic diameter of control ranged from 10–15 μm vs. 20 μm after treatment with NH 4 CH 3 CO 2 10 mM associated with large swollen nuclei , Back et al. ( ) . .. C6 Glioma Cell line (AmericanType Culture Collection (Rockville, MD)) -hyperammonemia - NH4Cl (5 mM) + resveratrol (100 μM) , In-vitro : astroglia cells , Optical microscopy , - ammonia induced astrocyte swelling / cell body retraction, and resveratrol prevented this effect - ammonia induced increased expression of cytokines, the TNF-α, IL-6 and IL-1β, which was partially reversed by resveratrol (TNF-a levels from 148 ± 13% to 109 ± 13%, IL-1β levels from 140 ± 9% to 110 ± 13%, and IL-6 from 135 ± 13% to 115 ± 16%, values expressed as percentage of control) , Bobermin et al. ( ) . .. Brain cell 3D culture hyperammonemia - NH4Cl (5 mM) + creatine (1 mM) , In-vitro : mixed-cell aggregates – from mechanically dissociated telencephalon of 16-day rat embryos , Optical microscopy , - ammonia induced astrocyte swelling, and creatine prevents this effect - NH 4 Cl alters AGAT, GAMT and SLC6A8 expression in glial cells but not in neurons - increased GAMT but repressed SLC6A8 mRNA expression in oligodendrocytes - creatine co-treatment under NH 4 Cl exposure represses AGAT and SLC6A8 in swollen astrocytes - decrease of endogenous synthesis of creatine under NH 4 Cl exposure - ammonia exposure impaired axonal growth in developing mixed cell aggregates - creatine prevented ammonia-induced axonal growth impairment in developing mixed cell aggregates - creatine did not prevent the ammonia-induced axonal growth impairment in developing neuron-enriched aggregates - neuronal fiber growth impairment under ammonium exposure, together with a decrease in medium size neurofilaments (NF-M) - in mature aggregates ammonia exposure does not alter axonal morphology → difference in vulnerability of the developing and adult brain - no significant effect was found for oligodendrocytes , Braissant et al. ( ) .

    Control:

    Article Title: Lessons on brain edema in HE: from cellular to animal models and clinical studies
    Article Snippet: Mouse – hyperammonemia - NH 4 CH 3 CO 2 (1–10 mM) , In-vitro : post-natal organotypic slice cultures – forebrain , Optical coherence tomography (OCT) - of cultured slices Confocal microscopy Immunoblotting , - ammonia for 3 days → evidence of tissue edema that is linked with astrocytic swelling - no significant changes in slice area were detected over 3 days at ammonia concentrations up to 10 mM - NH 4 CH 3 CO 2 10 mM resulted in macroscopic tissue swelling, with slice thickness increasing ~ 30%, treated: 441 ± 40 μm vs. control: 345 ± 33 μm - volume of GFAP-immunoreactivity was used as a marker of astrocyte cytoplasmic volume - the fractional volume of cortex occupied by GFAP- immunoreactive voxels progressively and significantly increased at concentrations of 1–10 mM of NH 4 CH 3 CO 2 - NH 4 CH 3 CO 2 10 mM resulted in 8% increase in volume of GFAP-immunoreactivity - no change in astrocytes number - neurons somatic diameter of control ranged from 10–15 μm vs. 20 μm after treatment with NH 4 CH 3 CO 2 10 mM associated with large swollen nuclei , Back et al. ( ) . .. C6 Glioma Cell line (AmericanType Culture Collection (Rockville, MD)) -hyperammonemia - NH4Cl (5 mM) + resveratrol (100 μM) , In-vitro : astroglia cells , Optical microscopy , - ammonia induced astrocyte swelling / cell body retraction, and resveratrol prevented this effect - ammonia induced increased expression of cytokines, the TNF-α, IL-6 and IL-1β, which was partially reversed by resveratrol (TNF-a levels from 148 ± 13% to 109 ± 13%, IL-1β levels from 140 ± 9% to 110 ± 13%, and IL-6 from 135 ± 13% to 115 ± 16%, values expressed as percentage of control) , Bobermin et al. ( ) . .. Brain cell 3D culture hyperammonemia - NH4Cl (5 mM) + creatine (1 mM) , In-vitro : mixed-cell aggregates – from mechanically dissociated telencephalon of 16-day rat embryos , Optical microscopy , - ammonia induced astrocyte swelling, and creatine prevents this effect - NH 4 Cl alters AGAT, GAMT and SLC6A8 expression in glial cells but not in neurons - increased GAMT but repressed SLC6A8 mRNA expression in oligodendrocytes - creatine co-treatment under NH 4 Cl exposure represses AGAT and SLC6A8 in swollen astrocytes - decrease of endogenous synthesis of creatine under NH 4 Cl exposure - ammonia exposure impaired axonal growth in developing mixed cell aggregates - creatine prevented ammonia-induced axonal growth impairment in developing mixed cell aggregates - creatine did not prevent the ammonia-induced axonal growth impairment in developing neuron-enriched aggregates - neuronal fiber growth impairment under ammonium exposure, together with a decrease in medium size neurofilaments (NF-M) - in mature aggregates ammonia exposure does not alter axonal morphology → difference in vulnerability of the developing and adult brain - no significant effect was found for oligodendrocytes , Braissant et al. ( ) .

    Cell Culture:

    Article Title: S100B Secretion in Astrocytes, Unlike C6 Glioma Cells, Is Downregulated by Lactate
    Article Snippet: .. The C6 glioma cell line was obtained from the American Type Culture Collection (Rockville, MA, USA) and cultured according to a previously described procedure [ , , , ]. ..

    Activity Assay:

    Article Title: [A Novel Rat Glioblastoma 101/8 Model: A Comparative PET-CT Study with C6 Rat model].
    Article Snippet: The development of new drugs in nuclear medicine for diagnosis or treatment (chemotherapy) of brain tumors, in particular gliomas, is inextricably linked with the use of tumor models in animals (usually rats).. Objective.. To compare the widely used glioma cell model C6 and the new experimental tissue model of glioblastoma 101.8.

    Modification:

    Article Title: Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition.
    Article Snippet: .. The C6 glioma cell line (CCL-107TM, ATCC) used in this study was maintained in Dulbecco’s Modified Eagle’s Medium (DMEM), supplemented with 10% fetal bovine serum and penicillin–streptomycin (10 U/mL). .. Primary glial cells were obtained from Gallus gallus domesticus embryos eight days (E8) after fertilization.

    Article Title: Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition
    Article Snippet: .. The C6 glioma cell line (CCL-107TM, ATCC) used in this study was maintained in Dulbecco’s Modified Eagle’s Medium (DMEM), supplemented with 10% fetal bovine serum and penicillin–streptomycin (10 U/mL). .. Primary glial cells were obtained from Gallus gallus domesticus embryos eight days (E8) after fertilization.



    Similar Products

    96
    ATCC murine glioma cell line c6
    Murine Glioma Cell Line C6, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6/pm41439468-272-31-39
    Average 96 stars, based on 1 article reviews
    murine glioma cell line c6 - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    94
    CLS Cell Lines Service GmbH glioma c6 cell line
    Glioma C6 Cell Line, supplied by CLS Cell Lines Service GmbH, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6+Cells/pm40518693-59-0-4
    Average 94 stars, based on 1 article reviews
    glioma c6 cell line - by Bioz Stars, 2026-09
    94/100 stars
      Buy from Supplier

    96
    ATCC rat glioma c6 cell lines
    Rat Glioma C6 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6%3B+Glioma%3B+Rat/pm41337659-828-8-17
    Average 96 stars, based on 1 article reviews
    rat glioma c6 cell lines - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    96
    ATCC rat c6 glioma cell line
    Rat C6 Glioma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6%3B+Glioma%3B+Rat/10__31594_slash_commagene__1780426-44-0-9
    Average 96 stars, based on 1 article reviews
    rat c6 glioma cell line - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    86
    Pasteur Institute rat glioma c6 cell lines
    Rat Glioma C6 Cell Lines, supplied by Pasteur Institute, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/87+cell+glioblastoma+human+line+mg+u/pm41220074-114-5-19
    Average 86 stars, based on 1 article reviews
    rat glioma c6 cell lines - by Bioz Stars, 2026-09
    86/100 stars
      Buy from Supplier

    96
    ATCC c6 rat glioma cell line
    C6 Rat Glioma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/C6/pm40773896-62-1-7
    Average 96 stars, based on 1 article reviews
    c6 rat glioma cell line - by Bioz Stars, 2026-09
    96/100 stars
      Buy from Supplier

    90
    National Centre for Cell Science c6 rat glioma adherent type colon cancer cell line
    C6 Rat Glioma Adherent Type Colon Cancer Cell Line, supplied by National Centre for Cell Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/c6+rat+brain+glioma+cell+line/pm40528055-152-0-12
    Average 90 stars, based on 1 article reviews
    c6 rat glioma adherent type colon cancer cell line - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    90
    National Centre for Cell Science c6 glioma cell line
    In vitro cell-based evaluation of Hybrid TMZ NCs in glioma cells. Cell cytotoxicity using MTT assay in (A) C6 and (B) <t>U87MG</t> glioma cells. Annexin-V/PI-based apoptosis assay in (C) C6 and (D) U87MG glioma cells. Coumarin-6-based cellular uptake assay. (E & F) Qualitative evaluation using microscopy in C6 and U87MG glioma cells, (G & H) Quantitative uptake using flow cytometry in C6 and U87MG glioma cells, respectively.
    C6 Glioma Cell Line, supplied by National Centre for Cell Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c6+glioma+cell+line/u87+cell+line/pmc12148390-79-2-10
    Average 90 stars, based on 1 article reviews
    c6 glioma cell line - by Bioz Stars, 2026-09
    90/100 stars
      Buy from Supplier

    Image Search Results


    In vitro cell-based evaluation of Hybrid TMZ NCs in glioma cells. Cell cytotoxicity using MTT assay in (A) C6 and (B) U87MG glioma cells. Annexin-V/PI-based apoptosis assay in (C) C6 and (D) U87MG glioma cells. Coumarin-6-based cellular uptake assay. (E & F) Qualitative evaluation using microscopy in C6 and U87MG glioma cells, (G & H) Quantitative uptake using flow cytometry in C6 and U87MG glioma cells, respectively.

    Journal: Asian Journal of Pharmaceutical Sciences

    Article Title: Enhancing temozolomide in vivo stability and efficacy through hybrid nanoconjugate approach for improved glioblastoma multiforme treatment

    doi: 10.1016/j.ajps.2025.101022

    Figure Lengend Snippet: In vitro cell-based evaluation of Hybrid TMZ NCs in glioma cells. Cell cytotoxicity using MTT assay in (A) C6 and (B) U87MG glioma cells. Annexin-V/PI-based apoptosis assay in (C) C6 and (D) U87MG glioma cells. Coumarin-6-based cellular uptake assay. (E & F) Qualitative evaluation using microscopy in C6 and U87MG glioma cells, (G & H) Quantitative uptake using flow cytometry in C6 and U87MG glioma cells, respectively.

    Article Snippet: C6 and U87MG glioma cell lines were obtained from the National Centre for Cell Sciences (NCCS, Pune, India), and were maintained in Dulbecco's Modified Eagle Medium (DMEM) and Minimum Essential Medium (MEM), respectively, supplemented with 10 % fetal bovine serum (FBS) and 1 % penicillin/streptomycin mixture, kept in an incubator at 37 °C with 5 % CO 2 .

    Techniques: In Vitro, MTT Assay, Apoptosis Assay, Microscopy, Flow Cytometry

    In vitro endo-lysosomal fate of Hybrid TMZ NCs in (A) C6 and (B) U87MG glioma cells.

    Journal: Asian Journal of Pharmaceutical Sciences

    Article Title: Enhancing temozolomide in vivo stability and efficacy through hybrid nanoconjugate approach for improved glioblastoma multiforme treatment

    doi: 10.1016/j.ajps.2025.101022

    Figure Lengend Snippet: In vitro endo-lysosomal fate of Hybrid TMZ NCs in (A) C6 and (B) U87MG glioma cells.

    Article Snippet: C6 and U87MG glioma cell lines were obtained from the National Centre for Cell Sciences (NCCS, Pune, India), and were maintained in Dulbecco's Modified Eagle Medium (DMEM) and Minimum Essential Medium (MEM), respectively, supplemented with 10 % fetal bovine serum (FBS) and 1 % penicillin/streptomycin mixture, kept in an incubator at 37 °C with 5 % CO 2 .

    Techniques: In Vitro